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Grants to USA IHEs, Agencies, and Community Organizations for Research Projects Related to COVID-19 Testing

RADx-UP CDCC Rapid Research Pilot Program


GrantWatch ID#

Funding Source
National Institutes of Health (NIH) - RADx-UP Coordination and Data Collection Center (CDCC)
Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

Geographic Focus
USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);
USA Compact Free Associations:The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Important Dates
LOI Date: 12/23/22
Deadline: 01/13/23 5:00 PM ET Save

Grant Description
Grants to USA and territories IHEs, government agencies, and community-based organizations for research projects related to Coronavirus (COVID-19) testing. Applicants must submit an LOI prior to submitting a full proposal. Funding is intended to increase access to COVID-19 testing for underserved and vulnerable populations.

The CDCC is pleased to solicit applications for its Rapid Research Pilot Program. This RFA describes the first solicitation of the CDCC Rapid Research Pilot Program. This pilot program provides an expedited funding mechanism (CDCC subawards) to evaluate the feasibility of implementing emerging COVID-19 testing technologies in underserved communities.

The goal of the program is to improve access to and uptake of diagnostic COVID-19 testing in communities of underserved and vulnerable populations. The purpose of the overall program is to better understand factors that have led to the disproportionate impact of COVID-19 on these groups, and develop interventions to reduce those disparities. The RADx-UP program has multiple components, which are summarized at

For the purpose of this RFA, populations that are underserved as well as populations that are COVID-19 vulnerable due to medical, geographic, and social factors, are defined below:

  • Underserved: NIH-designated health disparity populations known to experience barriers to accessing health coverage and basic health care services as well as disparities from COVID-19. A full description can be found at
  • COVID-19 medically and/or socially vulnerable populations: Residents of nursing homes and assisted living facilities; community-dwelling older adults; individuals with intellectual, developmental, sensory, or physical disabilities, cognitive impairment or dementia, or communication disorders; homeless populations; individuals involved with the criminal or juvenile justice systems (incarcerated or under community supervision); individuals with medical comorbidities known to increase risk of severe COVID-19, including heart failure and related cardiovascular conditions, diabetes mellitus, chronic lung disease, moderate or severe obesity, HIV/AIDS; pregnant and post-partum women; children and adolescents; individuals living in congregate housing such as shelters or residential treatment facilities; individuals in overcrowded or public housing; individuals with substance use disorders or serious mental illness; migrant and immigrant communities; residents of tribal lands or reservations; communities exposed to high rates of air pollution or other toxic exposures; and rural and remote communities.

This Rapid Research Pilot Program is intended to provide an expedited mechanism to assess the feasibility of integrating novel or emerging technologies into RADx-UP in coordination with the NIH-supported RADx initiatives. Applicants should address a number of potential challenges including the following three (3) key areas:

  1. Potential barriers to effective testing should be identified and addressed. Specific barriers may include:
    • Requirement of self-collection and self-administered testing versus the availability of a health professional for collection
    • Limited health literacy and ability to understand and interpret test methods, results, and follow up recommendations.
    • Secured return of test results and a requirement of online or digital delivery of test results
    • Test costs and reimbursement
  2. Alignment of the testing to the target population, or: is the test method appropriate, accounting for the interests, needs, and beliefs of the underserved community?
  3. Testing workflow and access. Are the tests administered in or outside the home? Are the tests scalable in terms of testing supplies shelf life, storage conditions, and vendor inventories? What are the requirements to report test results?


  • Others (see text field entitled "Additional Eligibility Criteria" for clarification)

Additional Eligibility Criteria
Eligible organizations are institutions of higher education, industry, state and local governments, and community-based organizations that have the infrastructure to manage such funding. Historically black colleges and universities (HBCUs), tribally controlled colleges and universities (TCCUs), Hispanic-serving institutions, and other minority-serving institutions are encouraged to apply. We are particularly interested in receiving proposals developed jointly with community-based organizations and encourage partnerships across these different types of organizations to form interdisciplinary teams, including public-private partnerships. Applications with multiple PIs (“co-PIs”) must identify one PI as the main contact PI, with primary responsibility for the administrative aspects of the pilot subaward.

The CDCC Rapid Research Pilot Program seeks an applicant pool that draws from the rich diversity of communities, populations, and groups in the U.S including the U.S. territories, tribal nations or organizations (American Indians, Alaska Natives, Native Hawaiians, and Other Pacific Islanders).

Proposals not considered responsive to this RFA include:
- Proposals involved in the early development of new tests or assays
- Proposed research studies conducted outside the United States or that propose foreign components
- Proposals intending to seek bridge funds or to use this mechanism as a supplement to an existing grant
- Proposals that are exclusively focused on community engagement should apply for the companion engagement Community Collaboration Grant

Pilot grant funds may not be budgeted for (1) travel to scientific meetings, or (2) meals (except during focus groups and other data collection/informational sessions and in accordance with NIH policy).

Pre-Proposal Conference
Register for RP2 Informational Webinar: Nov. 3, 1-2 p.m. ET:

Pre-Application Information
RADx-UP CDCC Rapid Pilot Program applications will be solicited up to 4 times per year. Applications are due by 5:00pm ET on the due date. It is expected that applicants will be notified within approximately 12 weeks of the submission deadline of a funding decision.

Application Cycles:

Letter of Interest due dates:
- November 19, 2021
- April 22, 2022
- August 26, 2022
- December 23, 2022

Full application due dates:
- December 10, 2021
- May 13, 2022
- September 16, 2022
- January 13, 2023

Expected notice of award dates:
- Week of January 31, 2022
- Week of July 4, 2022
- Week of November 7, 2022
- Week of March 6, 2023


About RADx-UP:

The RADx-UP program has multiple components, which are summarized

Community Engagement:

Estimated Size of Grant
The amount of the subaward for each Rapid Pilot is up to $200,000 in direct costs.

Term of Contract
The award is to be expended over one year.

Contact Information

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