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Grants to USA, Canada, and International Individuals for
Research Related to Alpha-1 Antitrypsin Deficiency

In-Cycle Grant Opportunity

Agency Type:

Foundation / Corporation

Funding Source:

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Alpha-1 Foundation

LOI Date:

09/24/21

Deadline Date:

02/18/22 11:59 PM ET - For Bridge Grants, Pilot and Feasibility Grants, Post Doctoral Research Fellowship Grants, and Research Grants. LOIs for Scientific Meeting Sponsorship and Travel Grants must be received at least two (2) months prior to the meeting or travel.

Description:

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Grants to USA, Canada, and International individuals for research projects related to Alpha-1 Antitrypsin Deficiency (Alpha-1). Applicants are required to submit a letter of intent prior to submitting a full proposal. Funding is intended to support a wide range of projects involving basic science, translational and clinical research, and ethical, legal, and social issues related to Alpha-1 Antitrypsin Deficiency (Alpha-1).

The Alpha-1 Foundation is committed to finding a cure for Alpha-1 Antitrypsin Deficiency and to improving the lives of individuals affected by Alpha-1 worldwide. The Grants Award Program is the Alpha-1 Foundation’s mechanism to fund a broad range of research that leads to improvements in the lives of people living with AAT Deficiency. The specific goals of the Program are:

  1. To promote basic science and clinical research related to the alpha1 antitrypsin protein and AAT Deficiency;
  2. To attract and train clinical researchers for the study of AAT Deficiency;
  3. To support and encourage established scientists to work on clinical problems and ethical, legal, and social issues within the field of AAT research (with a preference given to new investigators); and ultimately,
  4. To develop effective therapies for the clinical manifestations of AAT Deficiency.

Grant Categories:

  • Bridge Grant - The objective of this grant is to provide support for excellent AAT-related research projects that have been submitted to and approved by the National Institutes of Health (NIH), but cannot be supported by the available NIH funds.
  • Pilot and Feasibility Grant -  The objective of this grant is to provide funds to encourage the development and testing of new hypotheses and/or new methods in research areas relevant to AAT Deficiency. 
  • Postdoctoral Research Fellowship Grant -  The objective of this grant is to provide support for postdoctoral research fellows who are starting their research careers and are working in the laboratories of established researchers or conducting research with the mentorship of established researchers. In addition, this grant category is intended to provide support for postdoctoral research fellows who intend to pursue a career in AAT research. 
  • Research Grant - The objective of this grant is to provide funds to encourage the development of new information that contributes to the understanding of the basic biology of alpha-1 antitrypsin expression, and the pathogenesis/management of AAT Deficiency. In addition, consideration will be given to those projects that provide insight into the development of information that may contribute to new therapies for AAT Deficiency. 
  • Scientific Meeting Sponsorship - The objective of this grant is to provide support for scientific meetings, workshops or conferences relevant to AAT Deficiency and the Alpha-1 Foundation’s mission statement.
  • Travel Grants - There are 2 types of Travel Grants: Travel to Present Alpha-1 Research Grant and Travel to Receive Cross-Training Grant. 
  • Ethical, Legal and Social Issues (ELSI) Relating to Alpha-1 Antitrypsin Deficiency Grants - ELSI projects may be submitted under the grant categories of Pilot and Feasibility Grants, Postdoctoral Research Fellowships, and Research Grants.

For more information about grant categories, see https://www.alpha1.org/Alpha1/wp-content/uploads/2021/07/A1F-2021-22-In-Cycle-LOI-and-Full-Application-Instructions-FINAL-7.8.211.pdf#page=17

Newly funded in-cycle Investigators are invited to attend the Alpha-1 Foundation’s Awards Reception at the American Thoracic Society’s (ATS) International Conference. The Foundation will use monies from the grant award to help pay for Investigator’s travel to this reception. 

GrantWatch ID#:

GrantWatch ID#: 193008

Estimated Size of Grant:

- Bridge Grant: Up to $25,000
- Pilot and Feasibility Grant: Up to $75,000
- Postdoctoral Research Fellowship Grant: Up to $75,000/year
- Research Grant: Up to $100,000/year
- Scientific Meeting Sponsorship Grant: Up to $5,000
- Travel Grant: Up to $1,000

*The Alpha-1 Foundation requires that each applicant allocate $1,000 of the total budget to pay for travel to the Alpha-1 Foundation’s Biennial Investigators’ Meeting for the first year of the proposal’s period of performance.

Term of Contract:

- Bridge Grant: Up to 1 year
- Pilot and Feasibility Grant: Up to 1 year
- Postdoctoral Research Fellowship Grant: Up to 2 years
- Research Grant: Up to 2 years

Additional Eligibility Criteria:

The Foundation awards grants to a particular, designated individual and institution.

Postdoctoral Research Fellowship Grants: Applications will be accepted from candidates holding an M.D., Ph.D. or equivalent degrees who are interested in conducting basic science, clinical research, or ethic, legal, social issues studies related to AAT Deficiency.

Travel to Present Alpha-1 Research Grant Application: Candidates must have an M.D., Ph.D. or equivalent degree, and at least one year of recent research experience related to AAT Deficiency.

Pre-Application Information:

Timeline:
- Grant Announcement: July 12, 2021
- Letter of Intent (LOI) due to the Foundation (Deadline on ProposalCentral is 11:59 PM ET): September 24, 2021
- LOIs released to reviewers via ProposalCentral: October 6, 2021
- LOI reviews due to the Foundation (Deadline on ProposalCentral is 11:59 PM ET): November 11, 2021
- LOI applicants invited to submit grant applications via ProposalCentral: November 22, 2021
- Full grant applications due to the Foundation (Deadline on ProposalCentral is 11:59 PM ET): February 18, 2022
- Applications released to reviewers via ProposalCentral: February 28, 2022
- Applicants notified of funding decision: May 9-13, 2022
- Funding begins: July 1, 2022

For Scientific Meeting Sponsorship and Travel Grants, the electronic LOI must be received by the Alpha-1 Foundation at least two (2) months prior to the meeting or travel.

A full application is not necessary when requesting a Travel Grant or a Scientific Meeting Sponsorship Grant. The LOI should contain sufficient information for review. All applicants interested in applying for a Scientific Meeting Sponsorship or Travel Grant must first contact David Fernandez, Director of Research Administration, before preparing and submitting their LOI.

The first step in the process of a grant application to the Alpha-1 Foundation is to submit a Letter of Intent (LOI). The submission of an LOI is required for each grant category. An applicant must submit an LOI in order to submit a grant application.

The Alpha-1 Foundation requires that all applicants submit their full applications online using proposalCENTRAL. The full application forms are only accessible to LOI applicants who are invited by the Foundation to submit a full application. An applicant is not obligated to submit a full application if an LOI is submitted and invited for a full application. However, an applicant must submit an LOI in order to be eligible to submit a full application. A full application that is submitted without a LOI, or submitted outside of proposalCENTRAL, will result in an automatic denial of funding and the application will be returned to the investigator.

Any individual who received an Alpha-1 Foundation Research Grant in the previous year’s grant cycle is not eligible to apply for an in-cycle grant in the current cycle.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Submit LOI at https://proposalcentral.com/GrantOpportunities.asp?GMID=135

For information about the Foundation’s in-cycle grant opportunities, please contact David Fernandez, at dfernandez@alpha1.org or at (877) 228-7321 ext. 242.

Alpha-1 Foundation
3300 Ponce de Leon Blvd.
Coral Gables, FL 33134
Phone: 305-567-9888
Toll Free: (877) 2-CURE-A1 or (877) 228-7321

All inquiries or technical issues regarding proposalCENTRAL and the online application process should be directed to customer support at:
Phone: 703-964-5840, Toll-free phone: 1-800-875-2562
Email: pcsupport@altum.com

URL for Full Text (RFP):

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Israel

International country outside of the USA, Israel and Canada.

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